Radiation necrosis of the brain

Radiation necrosis of the brain (BRN) is most frequent and dangerous iatrogenic complication radiation therapy tumors non-tumor diseases base skull. The risk its development increases with an increase in amount radiation, single total doses due to synergy action adjuvant chemotherapy used. pathogenesis BRN based on damage microcirculatory bed tumor surrounding tissues edema impaired trophic neuroglia necrosis, which cases are irreversible. After treatment tumors, differential diagnosis carried out resumption growth or pseudoprogression requires use a set imaging methods. Treatment separate patients may consist surgical removal necrotic area, but it possible carry only drug corticosteroid anti-VEGF drugs that allow slow down BRN, improve quality life prolong its.